ABSTRACT
Background: Among the different CardioVascular (CV) manifestation of the COronaVIrus-related Disease (COVID) particular attention has been paid to arrhythmia and particularly to Atrial fibrillation (AF). The aim of our study was to assess the incidence of AF episodes in patients hospitalized for COVID and to evaluate its predictors and its relationship with in-hospital all-cause mortality. Method(s): We enrolled 3435 cases of SARS-CoV2 infection admitted in four hospitals in Northern Italy. We collected data on clinical history, vital signs, Intensive Care Unit (ICU) admission, laboratory tests and pharmacological treatment. AF incident and all-cause in-hospital mortality were considered as outcomes. Result(s): 145 (4.2%) patients develop AF during hospitalization, with a median time of 3 days (IQR: 0, 11.5) from admission. Incident AF patients were older and had lower eGFR, lower platelet and lymphocytes count and higher C-Reactive Protein (CRP), were admitted more frequently to ICU and more frequently died compared to subjects that didn't present AF. At the Cox regression model significant determinants of incident AF were older age (HR 1.070;95% CI: 1.048, 1.092), history of AF (HR 2.800;95% CI: 1.465, 5.351), ischemic heart disease (HR 0.324;95% CI: 0.130, 0.811) and ICU admission (HR 8.030;95% CI: 4.511, 14.292). Incident AF was a predictor of all-cause mortality (HR 1.679;95% CI: 1.170, 2.410), together with age (HR 1.053;95% CI: 1.042, 1.065), dementia (HR 1.553;95% CI 1.151, 2.095), platelet count (HR 0.997;95% CI: 0.996, 0.999) higher CRP (HR 1.004;95% CI: 1.003, 1.005) and eGFR (HR: 0.991;95% CI: 0.986, 0.996) Conclusion(s): AF present as the main arrhythmia in COVID-19 patients and its development during the hospitalization strongly relates with in-hospital mortality.
ABSTRACT
Background: Among the different CardioVascular (CV) manifestation of the COronaVIrus-related Disease (COVID) particular attention has been paid to arrhythmia and particularly to Atrial fibrillation (AF). The aim of our study was to assess the incidence of AF episodes in patients hospitalized for COVID and to evaluate its predictors and its relationship with in-hospital all-cause mortality. Method(s): We enrolled 3435 cases of SARS-CoV2 infection admitted in four hospitals in Northern Italy. We collected data on clinical history, vital signs, Intensive Care Unit (ICU) admission, laboratory tests and pharmacological treatment. AF incident and all-cause in-hospital mortality were considered as outcomes. Result(s): 145 (4.2%) patients develop AF during hospitalization, with a median time of 3 days (IQR: 0, 11.5) from admission. Incident AF patients were older and had lower eGFR, lower platelet and lymphocytes count and higher C-Reactive Protein (CRP), were admitted more frequently to ICU and more frequently died compared to subjects that didn't present AF. At the Cox regression model significant determinants of incident AF were older age (HR 1.070;95% CI: 1.048, 1.092), history of AF (HR 2.800;95% CI: 1.465, 5.351), ischemic heart disease (HR 0.324;95% CI: 0.130, 0.811) and ICU admission (HR 8.030;95% CI: 4.511, 14.292). Incident AF was a predictor of all-cause mortality (HR 1.679;95% CI: 1.170, 2.410), together with age (HR 1.053;95% CI: 1.042, 1.065), dementia (HR 1.553;95% CI 1.151, 2.095), platelet count (HR 0.997;95% CI: 0.996, 0.999) higher CRP (HR 1.004;95% CI: 1.003, 1.005) and eGFR (HR: 0.991;95% CI: 0.986, 0.996) Conclusion(s): AF present as the main arrhythmia in COVID-19 patients and its development during the hospitalization strongly relates with in-hospital mortality.
ABSTRACT
Background and Aims : Among the different CardioVascular (CV) manifestation of the CoronaVIrus-related Disease (COVID) particular attention has been paid to Atrial fibrillation (AF). The aim of our study was to assess the incidence of AF episodes in patients hospitalized for COVID and to evaluate its predictors and its relationship with in-hospital all-cause mortality. Method(s): We enrolled 3435 cases of SARS-CoV2 infection admitted in four hospitals in Northern Italy. We collected data on clinical history, vital signs, Intensive Care Unit (ICU) admission, laboratory tests and pharmacological treatment. AF incident and all-cause in-hospital mortality were considered as outcomes. Result(s): 145 (4.2%) patients develop AF during hospitalization, with a median time of 3 days (IQR:0,11.5) from admission. Incident AF patients were older and had lower eGFR, lower platelet and lymphocytes count and higher C-Reactive Protein (CRP), were admitted more frequently to ICU and more frequently died compared to subjects that didn't present AF. At the Cox regression model significant determinants of incident AF were older age (HR 1.070;95% CI: 1.048-1.092), history of AF (HR 2.800;95% CI:1.465-5.351), ischemic heart disease (HR 0.324;95% CI: 0.130-0.811) and ICU admission (HR 8.030;95% CI:4.511, 14.292). Incident AF was a predictor of all-cause mortality (HR 1.679;95% CI:1.170-2.410), together with age (HR 1.053;95% CI: 1.042-1.065), dementia (HR 1.553;95% CI:1.151-2.095), platelet count (HR 0.997;95% CI:0.996-0.999) higher CRP (HR 1.004;95% CI:1.003-1.005) and eGFR (HR: 0.991;95% CI:0.986-0.996) Conclusion(s): AF present as the main arrhythmia in COVID-19 patients and its development during the hospitalization strongly relates with in-hospital mortality. Copyright © 2022
ABSTRACT
Introduction: Among the different CardioVascular (CV) manifestation of the COronaVIrus-related Disease (COVID) particular attention has been paid to arrhythmia and particularly to Atrial fibrillation (AF). Aim(s): To assess the incidence of AF episodes in patients hospitalized for COVID and to evaluate its predictors and its relationship with inhospital all-cause mortality. Method(s): We enrolled 3435 cases of SARS-CoV2 infection admitted in four hospitals in Northern Italy. We collected data on clinical history, vital signs, Intensive Care Unit (ICU) admission, laboratory tests and pharmacological treatment. AF incident and all-cause inhospital mortality were considered as outcomes. Result(s): 145 (4.2%) patients develop AF during hospitalization, with a median time of 3 days (IQR: 0, 11.5) from admission. Incident AF patients were older and had lower eGFR, lower platelet and lymphocytes count and higher C-Reactive Protein (CRP), were admitted more frequently to ICU and more frequently died compared to subjects that didn't present AF. At the Cox regression model significant determinants of incident AF were older age (HR 1.070;95% CI: 1.048, 1.092), history of AF (HR 2.800;95% CI: 1.465, 5.351), ischemic heart disease (HR 0.324;95% CI: 0.130, 0.811) and ICU admission (HR 8.030;95% CI: 4.511, 14.292). Incident AF was a predictor of all-cause mortality (HR 1.679;95% CI: 1.170, 2.410), together with age (HR 1.053;95% CI: 1.042, 1.065), dementia (HR 1.553;95% CI 1.151, 2.095), platelet count (HR 0.997;95% CI: 0.996, 0.999) higher CRP (HR 1.004;95% CI: 1.003, 1.005) and eGFR (HR: 0.991;95% CI: 0.986, 0.996) Conclusion(s): AF present as the main arrhythmia in COVID-19 patients and its development during the hospitalization strongly relates with in-hospital mortality.
ABSTRACT
Objective: Among the different CardioVascular (CV) manifestation of the COronaVIrus- related Disease (COVID) particular attention has been paid to arrhythmia and particularly to Atrial fibrillation (AF). The aim of our study was to assess the incidence of AF episodes in patients ospitalisat for COVID and to evaluate its predictors and its relationship with in-hospital all-cause mortality. Design and method: We enrolled 3435 cases of SARS-CoV2 infection admitted in four hospitals in Northern Italy. We collected data on clinical history, vital signs, Intensive Care Unit (ICU) admission, laboratory tests and pharmacological treatment. AF incident and all-cause in-hospital mortality were considered as outcomes. Results: 145 (4.2%) patients develop AF during ospitalisation, with a median time of 3 days (IQR: 0, 11.5) from admission. Incident AF patients were older and had lower eGFR, lower platelet and lymphocytes count and higher C-Reactive Protein (CRP), were admitted more frequently to ICU and more frequently died compared to subjects that didn't present AF. At the Cox regression model significant determinants of incident AF were older age (HR 1.070;95% CI: 1.048, 1.092), history of AF (HR 2.800;95% CI: 1.465, 5.351), ischemic heart disease (HR 0.324;95% CI: 0.130, 0.811) and ICU admission (HR 8.030;95% CI: 4.511, 14.292). Incident AF was a predictor of all-cause mortality (HR 1.679;95% CI: 1.170, 2.410), together with age (HR 1.053;95% CI: 1.042, 1.065), dementia (HR 1.553;95% CI 1.151, 2.095), platelet count (HR 0.997;95% CI: 0.996, 0.999) higher CRP (HR 1.004;95% CI: 1.003, 1.005) and eGFR (HR: 0.991;95% CI: 0.986, 0.996) Conclusions: AF present as the main arrhythmia in COVID-19 patients and its development during the ospitalisation strongly relates with in-hospital mortality.
ABSTRACT
From two COVID-19-related deaths, samples of lung, heart and kidney were collected and processed for Transmission and Scanning Electron Microscopy (TEM and SEM) with the aim of identifying the virus. Virions of SARS-CoV-2 were found in all tissues by TEM and SEM, corroborating the hypothesis that the virus enters the cells of different organs. This is the first report identifying SARS-CoV-2 in different human tissues by TEM and SEM.